Course Objectives:

1. Know neurobiology of nicotine addiction

2. Know nicotine metabolism vis CYP2A6 + pharmacokinetics

3. Know nicotine cholinergic receptor subunits

4. Know psychoactive effects of nicotine

5. Know role of nicotine metabolism as determinant of tobacco use and dependence

6. Know pharmacotherapy for smoking cessation

•     a. Doses of NRT used for number of cigarettes smoked/day
•     b. Mechanism of action for smoking cessation drugs, including receptors and     neurotransmitters
•     c. Combination pharmacotherapy
•     d. Adverse effects and contraindications
•     e. Comparative efficacy