Neurobiology of Alcohol and Drug Addiction

Learning Objectives

As a result of participating in this lecture learners should have a working knowledge of the following topics, essential to competency in addiction medicine and identify areas where more study may be needed:

  1. Brain reward circuits
  2. Neurotransmitters: Where and what type are relevant in addictive disorders?
  3. Action of psychoactive substances on brain circuits and neurotransmitters
  4. Genetic basis for neurobiological addictive disease vulnerability and treatment response
  5. Implication of neurobiological principles on treatment and recovery
  6. Animal models of addiction
  7. Cellular and molecular mechanisms in addiction, including neuroadaptation, epigenetic phenomena, etc.
  8. Neuroimaging of addiction and related phenomena, i.e., craving, relapse, recovery.


Course summary
Available credit: 
  • 0.75 AAPA
  • 0.75 AMA Category 1
  • 0.75 CAADAC
Course opens: 
Course expires: 

George F. Koob, PhD
Dr. Koob is Director of the National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health, Washington, DC.  As an authority on alcoholism, drug addiction and stress, he has contributed to our understanding of the neurocircuitry associated with the acute reinforcing effects of alcohol and drugs of abuse and the neuroadaptations of the reward and stress circuits associated with the transition to dependence.  Dr. Koob has published over 600 peer reviewed papers and several books including the “Neurobiology of Addiction,” a comprehensive treatise on emerging research in the field.

Dr. Koob has no relevant financial relationships to disclose

Available Credit

  • 0.75 AAPA
  • 0.75 AMA Category 1
  • 0.75 CAADAC


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